Hi, yes you can. For that, you’ll have to enable “Customized htaccess” under general settings tab, and add HMWP rules to the htaccess file manually by clicking on “manual configuration” button and then following the mentioned steps. Now, remove the rewrite rule from htaccess for the desired plugin.
But can you please let us know what is the plugin name that requires basic address with /wp-content/ and what error you get if you rename that plugin’s path with HMWP?