I found final solution.
In the wp-config file multisite settings was wrong.
When I fixed
define(‘DOMAIN_CURRENT_SITE’, ‘main-root-doman-name.com’);
define(‘SITE_ID_CURRENT_SITE’, 5);
define(‘BLOG_ID_CURRENT_SITE’, 5);
in may case my main site ID in wp multisite enviroment is 5.
When this settings is not correct HMWP cant save settings and make several issues.
You cant use subdomain for main site with HMWP.
Its not bug, its a special problem when you upgrade SINGE WP to MULTI WP, and this settings not correct.